Research
Hundreds of investigators, thousands of patients, and decades of research have poured into our scientifically-backed dietary supplements.
The Scientific Basis for [QUELL]plus™: While serving as pain clinicians on a hospital's acute pain service, the pharmacist founders of neurii health noted surprising success with a sequential combination of an anti-neuropathic drug, a mild NMDA receptor antagonist, and an anti-inflammatory agent. Understanding the impact this combination had on the most challenging cases of acute pain, while witnessing first-hand the shortcomings of available therapies for chronic pain, they began researching and developing neurii health's first oral dietary supplement to support people living with pain using these same exact principles of synergy and combined mechanisms.
[QUELL]plus™ (palmitoylethanolamide + magnesium + luteolin) Literature Review:
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Van Noord BA, Berger J, Motamed A. Opioid Resistant Pain Successfully Managed with Magnesium, Lidocaine and Ketorolac in the Post-Anesthesia Care Unit: A Case Series. J Anesthe Clinic Res. 2012;3:196. Zanza Christian, Longhitano Yaroslava , Lin Edwin, et al. Intravenous Magnesium - Lidocaine - Ketorolac Cocktail for Postoperative Opioid Resistant Pain: A Case Series of Novel Rescue Therapy. Reviews on Recent Clinical Trials. 2021;16(3). Lang-Illievich K, Klivinyi C, Rumpold-Seitlinger G, Dorn C, Bornemann-Cimenti H. The Effect of Palmitoylethanolamide on Pain Intensity, Central and Peripheral Sensitization, and Pain Modulation in Healthy Volunteers—A Randomized, Double-Blinded, Placebo-Controlled Crossover Trial. Nutrients. 2022; 14(19):4084. Pickering, E., Steels, E.L., Steadman, K.J. et al. A randomized controlled trial assessing the safety and efficacy of palmitoylethanolamide for treating diabetic-related peripheral neuropathic pain. Inflammopharmacol (2022). Scuteri D, Guida F, Boccella S, Palazzo E, Maione S, Rodríguez-Landa JF, Martínez-Mota L, Tonin P, Bagetta G, Corasaniti MT. Effects of Palmitoylethanolamide (PEA) on Nociceptive, Musculoskeletal and Neuropathic Pain: Systematic Review and Meta-Analysis of Clinical Evidence. Pharmaceutics. 2022; 14(8):1672. (2021) Palmitoylethanolamide: A Potential Alternative to Cannabidiol, Journal of Dietary Supplements. Heiliczer S, Wilensky A, Gaver T, Georgiev O, Hamad S, Nemirovski A, Hadar R, Sharav Y, Aframian DJ, Tam J, Haviv Y. Salivary Endocannabinoid Profiles in Chronic Orofacial Pain and Headache Disorders: An Observational Study Using a Novel Tool for Diagnosis and Management. International Journal of Molecular Sciences. 2022; 23(21):13017. Lind J., Stensson N., Gerdle B., & Ghafouri N. (2022). Levels of bioactive endogenous lipids and health-related quality of life in Chronic Idiopathic Axonal Polyneuropathy. Upsala Journal of Medical Sciences, 127(1). Ayoze González Hernández, Palmitoylethanolamide-based nutraceutical Calmux® in preventive treatment of migraine, Clinical Neurology and Neurosurgery, Volume 218, 2022. Ugo Indraccolo, Alessandro Favilli, Arianna Dell’Anna, Antonio Di Francesco, Barbara Dionisi, Emilio Giugliano, Filippo Murina, Erica Stocco, "Looking for Responders among Women with Chronic Pelvic Pain Treated with a Comicronized Formulation of Micronized Palmitoylethanolamide and Polydatin", BioMed Research International, vol. 2022, Article ID 8620077, 10 pages, 2022. Briskey, D. , Ebelt, P. , Steels, E. , Subah, S. , Bogoda, N. and Rao, A. (2022) Efficacy of Palmitoylethanolamide (Levagen+TM) Compared to Ibuprofen for Reducing Headache Pain Severity and Duration in Healthy Adults: A Double-Blind, Parallel, Randomized Clinical Trial. Food and Nutrition Sciences, 13, 690-701. I D Chaurasia, Kunal Vaisya, Mahim Koshariya, et al. Therapeutic Benefit of Palmitoylethanolamide in the Management of Trigeminal Neuralgia. Int J Neurol Neurosurg. 2020;12(3):137-141. Rankin L, Fowler CJ. The Basal Pharmacology of Palmitoylethanolamide. International Journal of Molecular Sciences. 2020; 21(21):7942. Paladini A, Fusco M, Cenacchi T, Schievano C, Piroli A, Varrassi G. Palmitoylethanolamide, a Special Food for Medical Purposes, in the Treatment of Chronic Pain: A Pooled Data Meta-analysis. Pain Physician. 2016 Feb;19(2):11-24. PMID: 26815246. Cordaro M, Cuzzocrea S, Crupi R. An Update of Palmitoylethanolamide and Luteolin Effects in Preclinical and Clinical Studies of Neuroinflammatory Events.Antioxidants. 2020; 9(3):216. https://doi.org/10.3390/antiox9030216 , , and (2016) Palmitoylethanolamide for the treatment of pain: pharmacokinetics, safety and efficacy. Br J Clin Pharmacol, 82: 932– 942. Hesselink J, Kopsky D. Palmitoylethanolamide, a neutraceutical, in nerve compression syndromes: efficacy and safety in sciatic pain and carpal tunnel syndrome. J Pain Res. 2015;8:729-734 Artukoglu BB, Beyer C, Zuloff-Shani A, Brener E, Bloch MH. Efficacy of Palmitoylethanolamide for Pain: A Meta-Analysis. Pain Physician. 2017 Jul;20(5):353-362. PMID: 28727699. Paterniti, I., Impellizzeri, D., Di Paola, R., Navarra, M., Cuzzocrea, S., & Esposito, E. (2013). A new co-ultramicronized composite including palmitoylethanolamide and luteolin to prevent neuroinflammation in spinal cord injury. Journal of neuroinflammation, 10(1), 1-11. , , , et al. The endocannabinoid system and related lipids as potential targets for the treatment of migraine-related pain. Headache. 2022; 62: 227– 240. Rinaldi M, Di Lena S, Luccarelli D, Bettocchi C. A Palmitoylethanolamide (PEA) and Magnesium Based Product (PEAMag) Reduces the Pain and Improves Quality of Life in Patients Affected by Acute and Chronic Pelvic Pain. Clin Case Rep Int. 2022; 6: 1337. Bonetti M, Lauritano D, Ottaviani GM, Fontana A, Zambello A, Della Gatta L, Muto M, Carinci F. Oxygen–Ozone Therapy Associated with Alpha Lipoic Acid Plus Palmitoylethanolamide and Myrrh versus Ozone Therapy in the Combined Treatment of Sciatic Pain Due to Herniated Discs: Observational Study on 318 Patients. International Journal of Environmental Research and Public Health. 2022; 19(9):5716. Nohales Alfonso F. Experience with nutraceutical supplements in the treatment of pelvic pain in gynaecology: case reports. Drugs Context. 2022 Jan 12;11:2021-10-8. Taheri Y, Sharifi-Rad J, Antika G, Yılmaz YB, Tumer TB, Abuhamdah S, Chandra S, Saklani S, Kılıç CS, Sestito S, Daştan SD, Kumar M, Alshehri MM, Rapposelli S, Cruz-Martins N, Cho WC. Paving Luteolin Therapeutic Potentialities and Agro-Food-Pharma Applications: Emphasis on In VivoPharmacological Effects and Bioavailability Traits. Oxid Med Cell Longev. 2021 Sep 20;2021. Colosimo S, Balzani E, Cioni R, et al. Supplementation with Anti-inflammatory Nutraceutical Products in the Management of Chronic Pelvic Pain: A Narrative Review. Current Topics in Nutraceutical Research. 2022;20(2):265-275. Giulia Magni, Benedetta Riboldi, Katia Petroni, Stefania Ceruti, Flavonoids bridging the gut and the brain: Intestinal metabolic fate, and direct or indirect effects of natural supporters against neuroinflammation and neurodegeneration, Biochemical Pharmacology, Volume 205, 2022. , , , . Luteolin as a modulator of skin aging and inflammation. BioFactors. 2021; 47: 170– 180. , , , et al. Neuroprotective effects of flavone luteolin in neuroinflammation and neurotrauma. BioFactors. 2021; 47: 190– 197. , , , . Luteolin, inflammation and cancer: Special emphasis on gut microbiota. BioFactors. 2021; 47: 181– 189. , , , et al. Powerful anti-inflammatory action of luteolin: Potential increase with IL-38. BioFactors. 2021; 47: 165– 169. Zhenyu Wang, Maomao Zeng, Zhaojun Wang, et al. Dietary Luteolin: A Narrative Review Focusing on Its Pharmacokinetic Properties and Effects on Glycolipid Metabolism. Journal of Agricultural and Food Chemistry 2021 69 (5), 1441-1454. Allah Rakha, Nehal Umar, Roshina Rabail, et al. Anti-inflammatory and anti-allergic potential of dietary flavonoids: A review. Biomedicine & Pharmacotherapy, Volume 156, 2022. Shin H-J, Na H-S, Do S-H. Magnesium and Pain. Nutrients. 2020; 12(8):2184. Xiaoqing Kuang, Jiachi Chiou, Kenneth Lo, et al. Magnesium in joint health and osteoarthritis. Nutrition Research,Volume 90,2021,Pages 24-35. Fiorentini D, Cappadone C, Farruggia G, Prata C. Magnesium: Biochemistry, Nutrition, Detection, and Social Impact of Diseases Linked to Its Deficiency. Nutrients. 2021; 13(4):1136. Urits I, Jung JW, Amgalan A, Fortier L, Anya A, Wesp B, Orhurhu V, Cornett EM, Kaye AD, Imani F, Varrassi G, Liu H, Viswanath O. Utilization of Magnesium for the Treatment of Chronic Pain. Anesth Pain Med. 2021 Feb 6;11(1):e112348. Yousef AA, Al-Deeb AE. A double-blinded randomised controlled study of the value of sequential intravenous and oral magnesium therapy in patients with chronic low back pain with a neuropathic component. Anaesthesia. 2013;68(3):260–6. Brotini S. Palmitoylethanolamide/Luteolin as Adjuvant Therapy to Improve an Unusual Case of Camptocormia in a Patient with Parkinson's Disease: A Case Report. Innov Clin Neurosci. 2021 Oct-Dec;18(10-12):12-14. |
